The victim, 47-year-old Carlton McCloud, was found injured on Old Kent Road in the early morning of January 9 and died at the scene.
Detectives have now charged two people more following the fatal stabbing.
Matthew Henry, 39, of Coopers Road and Nicole Quamina, 34, of no fixed address, will both appear in custody at Bromley Magistrates’ Court on January 13 after being charged on January 12.
Police previously confirmed that the stabbing occurred inside a home – close to where members of the public found him.
A post mortem listed the cause of death as sharp force trauma to the chest.
Two other suspects, a 54-year old man and a 38-year-old woman, were also arrested on suspicion of murder on January 9 and have since been released on bail.
A spokesperson for Metropolitan Police said: “Detectives investigating a fatal stabbing in Southwark have charged two people with murder.
Matthew Henry, 39 (06.12.84) of Coopers Road SE1 and Nicole Quamina, 34 (27.06.89) of no fixed address will both appear in custody at Bromley Magistrates’ Court on Saturday, 13 January. Both were charged on Friday, 12 January.
“At around 06:50hrs on Tuesday, 9 January, officers were called to reports of an injured man on Old Kent Road, SE1.
“Despite the efforts of emergency services, the victim – Carlton McCloud, aged 47 – died at the scene. His next of kin have been informed and are being supported.
“A post mortem examination found the cause of death to be sharp force trauma to the chest.
“Two others have been arrested on suspicion of murder as part of the investigation.
“On Tuesday, 9 January, a 54-year old man [A] and a 38-year-old woman [B] were arrested and have since been bailed.”
